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Development of electrochemical imaging methods using micro-electrode arrays and microfluidic networks

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dc.contributor.authorWydallis, John B., author
dc.contributor.authorHenry, Charles S., advisor
dc.contributor.authorVan Orden, Alan, committee member
dc.contributor.authorBarisas, B. George, committee member
dc.contributor.authorMcNaughton, Brian R., committee member
dc.contributor.authorDandy, David S., committee member
dc.date.accessioned2016-08-18T23:10:01Z
dc.date.available2016-08-18T23:10:01Z
dc.date.issued2016
dc.description.abstractDistribution of molecules over space and time drive a multitude of macroscopic and microscopic biological processes. There is a need to design novel imaging techniques that can map molecular distributions with spatiotemporal resolution. In this thesis, new electrochemical approaches to provide spatiotemporal imaging are presented. The bulk of this work utilizes high-density platinum micro-electrode arrays fabricated using complementary metal oxide semiconductor (CMOS) fabrication techniques as well as microfluidics and carbon-based electrodes fabricated using soft lithography fabrication techniques. The systems described in this dissertation focus on quantification of biologically relevant neurotransmitters, mainly catecholamines and nitric oxide with concentration ranges from nM to mM. The pitch, or resolution between two "pixels" of electrochemical data, was 250 µm for microfluidic based sampling methods and 12.5 µm for the CMOS based sensors. Descriptions of fabrication methods for the carbon based electrodes and CMOS electrodes are described in this work. Finally, potential future directions of this technology is discussed in the final chapter.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierWydallis_colostate_0053A_13622.pdf
dc.identifier.urihttp://hdl.handle.net/10217/176594
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectCMOS
dc.subjectelectrode arrays
dc.subjectoptical profilometry
dc.subjectelectrochemical imaging
dc.subjectchemical gradients
dc.subjectmicrofluidics
dc.titleDevelopment of electrochemical imaging methods using micro-electrode arrays and microfluidic networks
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineChemistry
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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