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Macrophage receptor-mediated recognition, response and treatment of Leishmania major infection

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dc.contributor.authorNelson, Keith G., author
dc.contributor.authorMason, Gary, advisor
dc.contributor.authorGentry-Weeks, Claudia, committee member
dc.contributor.authorZeidner, Nordin, committee member
dc.contributor.authorBamburg, James, committee member
dc.date.accessioned2007-01-03T08:20:44Z
dc.date.available2007-01-03T08:20:44Z
dc.date.issued2011
dc.description.abstractWe investigate the role of macrophage receptors in the recognition of Leishmania major and response to the parasite, focusing on complement receptors (CR). CR1 and CR3 are the main complement receptors on murine macrophages, recognizing specific parasite surface antigens and parasites opsonized by complement component 3 (C3). Utilizing C3-deficient mice, we show a clear role for complement in enhancing parasite infectivity, and recognition of and response to L. major by the murine host. In our in vitro experiments blocking CR1 and CR3, there is a clear effect of the route of parasite recognition and entry into the macrophage on parasite phagocytosis and cytokine response to infection by L. major, although Th1/Th2 bias is unaffected by blocking complement receptors. Using parasite strains lacking in the two most common surface molecules of L. major (LPG and gp63), we show a strong role for gp63 in the interaction with C3 and complement receptors, particularly CR3. Lastly, we demonstrate the utility of targeting anti-leishmanial therapeutics in infected hosts to the macrophage through another macrophage receptor, the scavenger receptor.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierNelson_colostate_0053A_10805.pdf
dc.identifierETDF2011400264MIPA
dc.identifier.urihttp://hdl.handle.net/10217/70462
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectmacrophage
dc.subjectnanodisk
dc.subjectcomplement
dc.subjectgp63
dc.subject.lcshLeishmania
dc.titleMacrophage receptor-mediated recognition, response and treatment of Leishmania major infection
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineMicrobiology, Immunology, and Pathology
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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