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A simple lumped parameter model of the cardiovascular system

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dc.contributor.authorPhillips, Canek Moises Luna, author
dc.contributor.authorDasi, Lakshmi Prasad, advisor
dc.contributor.authorJames, Susan P., committee member
dc.contributor.authorKawcak, Christopher E., committee member
dc.date.accessioned2007-01-03T05:00:51Z
dc.date.available2007-01-03T05:00:51Z
dc.date.issued2011
dc.description.abstractCongestive heart failure is caused when untreated heart diseases affect malfunction in the heart to a point where the heart can no longer pump enough blood to the body. The additional energy cost taxed onto the heart by heart diseases is the root cause of congestive heart failure. Currently, a disease severity guideline is used in the medical field to differentiate disease cases and their relative risk of causing congestive heart failure. The current disease severity guideline does not take into consideration workload when assessing the severity of a disease case. A zero-dimensional computational model of the left ventricle was developed to simulate physiological and pathophysiological characteristics to quantify workload of hypothetical normal and diseased patient cases. The development of the computational model has revealed that workload calculation possesses utility in differentiating the severity of risk that left ventricular diseases have on affecting congestive heart failure. Results of heart disease simulations for aortic stenosis, aortic regurgitation, mitral regurgitation, and hypertension show the energy cost the diseases impose on the left ventricle compared to a normal patient model. Additional results of simulations with combined mild cases of heart diseases show an amplified impact on energy cost - more than the energy cost of individual mild cases added together separately. The calculation of workload in computational simulations is an important step towards using workload as a universal indicator of risk of development of congestive heart failure and updating treatment guidelines so that prevention of congestive heart failure is more successful.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierPhillips_colostate_0053N_10632.pdf
dc.identifier.urihttp://hdl.handle.net/10217/46905
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectcongestive heart failure
dc.subjectlumped parameter model
dc.subjectleft ventricle workload
dc.subjectenergy cost
dc.subjectdirect workload calculation
dc.titleA simple lumped parameter model of the cardiovascular system
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineMechanical Engineering
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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