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A single session of moderate exercise, without energy deficit, may reduce svcam-1 concentrations in young, sedentary females

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dc.contributor.authorKrause, Molly Annamarie, author
dc.contributor.authorMelby, Christopher, advisor
dc.contributor.authorHickey, Matthew, committee member
dc.contributor.authorNelson, Tracy, committee member
dc.date.accessioned2007-01-03T04:52:26Z
dc.date.available2007-01-03T04:52:26Z
dc.date.issued2010
dc.description.abstractPurpose: Cardiovascular disease remains the number one cause of death within the United States and globally [1, 2]. Postprandial lipemia and vascular adhesion molecules are becoming more widely recognized as biomedical makers associated with increased risk of developing CVD [3-5]. It has been well established that moderate exercise can improve some aspects of postprandial metabolism such as decreased triglycerides and improved insulin sensitivity [6]. However, there is limited data regarding the effect of prior moderate exercise on attenuating postprandial response specific to adhesion molecules [7, 8]. The purpose of this study was to determine the effects of a single bout of acute exercise, with energy replacement, on plasma soluble vascular adhesion molecule-1 (sVCAM-1), a marker of endothelial dysfunction, measured during fasting and in response to a high-fat, high-carbohydrate meal in young, non-obese, sedentary females. Methods: Eight, non-obese (x body mass index=24.6 kg/m2), habitually sedentary females (x age= 19.6 y) participated in this study. Following preliminary testing, each subject completed two trials in random order: 1) Exercise (Ex) 2) Non-exercise (Non-Ex). Each trial took place over 2 days. On the evening of day 1, subjects either rested (Non-Ex) or completed a cycle ergometer exercise bout at 65% peak heart rate, eliciting net exercise energy expenditure of ~285kcalories. On the morning of day 2 of each trial a fasting venous blood sample was drawn for measurement of sVCAM-1, followed by the consumption of a high-fat, high-sugar meal by each participant. Postprandial venous blood samples were then taken over at 2, 4, and 6 hours following meal ingestion for measurement plasma sVCAM-1 concentrations. Results: There was no significant treatment by time interaction on sVCAM-1 concentrations, nor was there a significant main effect of time. There was a significant condition effect on circulating soluble VCAM-1 concentrations such that concentrations were lower before and following the high-fat, high-sugar meal challenge for the EX compare to the NonEx condition. Conclusions: Results from the current study suggest that a single session of moderate exercise, without an energy deficit, may reduce sVCAM-1 concentrations in young, sedentary females. However, this finding must be viewed with caution owing to possible issues with thesVCAM-1 measurements, and the assay repeated prior to drawing any conclusions about the effect of acute exercise on circulating sVCAM-1 concentrations measured the morning after exercise.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierKrause_colostate_0053N_10166.pdf
dc.identifierETDF2010200114FSHN
dc.identifier.urihttp://hdl.handle.net/10217/44965
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectsVCAM-1
dc.subjectfemales
dc.subjectexercise
dc.subjectenergy deficit
dc.subjectadhesion molecules
dc.subject.lcshCell adhesion molecules
dc.subject.lcshSedentary women
dc.subject.lcshYoung women -- Nutrition
dc.titleA single session of moderate exercise, without energy deficit, may reduce svcam-1 concentrations in young, sedentary females
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineFood Science and Human Nutrition
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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