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Modeling HIV evolution from SIV using a humanized mouse model

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dc.contributor.authorCurlin, James, author
dc.contributor.authorSchmitt, Kimberly, author
dc.contributor.authorRemling-Mulder, Leila, author
dc.contributor.authorStenglein, Mark, author
dc.contributor.authorO'Connor, Shelby, author
dc.contributor.authorMarx, Preston, author
dc.contributor.authorAkkina, Ramesh, author
dc.date.accessioned2017-11-14T13:49:19Z
dc.date.available2017-11-14T13:49:19Z
dc.date.issued2017
dc.description.abstractHuman Immunodeficiency Virus (HIV) is believed to have arisen in humans as a result of multiple independent cross-species exposures to Simian Immunodeficiency Viruses. Here the serial passaging of SIV in humanized mice across several generations recapitulates the genetic changes that make have facilitated such cross-species transmissions. Viral adaptation to the hu-mice was determined via qRT-PCR analysis of plasma viral loads and observation of CD4+ T-cell depletion. SIVs at various stages of adaptation from different generations were analyzed through Next Generation Sequencing (NGS). Many non-synonymous mutations were observed across each passage that may be responsible for improved cross-species transmission and adaptation.en_US
dc.format.mediumborn digital
dc.format.mediumStudent works
dc.format.mediumposters
dc.identifier.urihttps://hdl.handle.net/10217/184934
dc.languageEnglishen_US
dc.language.isoengen_US
dc.publisherColorado State University. Librariesen_US
dc.relation.ispartof2017 Projects
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectSIV
dc.subjectHIV
dc.subjecthumanized mice
dc.subjectviral evolution
dc.titleModeling HIV evolution from SIV using a humanized mouse modelen_US
dc.title.alternative076 - James Zachary Curlinen_US
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