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Design of a gait acquisition and analysis system for assessing the recovery in a classical murine model of Parkinson's disease

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dc.contributor.authorDamale, Pranav, author
dc.contributor.authorChong, Edwin K. P., advisor
dc.contributor.authorTjalkens, Ronald, committee member
dc.contributor.authorEbert-Uphoff, Imme, committee member
dc.date.accessioned2016-01-11T15:13:50Z
dc.date.available2016-01-11T15:13:50Z
dc.date.issued2015
dc.description.abstractGait deficits are important clinical symptoms of Parkinson's disease (PD). Data focusing on gait can be used to measure recovery of motor impairments in rodents with systemic dopamine depletion. This thesis presents a design for a gait acquisition and analysis system able to capture paw strikes of a mouse, extract their positions and timing data, and report quantitative gait metrics to the operator. These metrics can then be used to evaluate the gait changes in mice. This work presents the design evaluation of the system, from initial cellphone captured video concepts through prototyping and testing to the final implementation. The system utilizes a GoPro camera, optimally lit walkway design, image processing techniques to capture footfalls, and algorithms for their quantitative assessment. The results gained from live animal study with methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced murine model of PD and treated with 1,1-bis(3'-indolyl)-1-(p-chlorophenyl)methane (C-DIM12) are presented, and it is shown how the quantitative measurements can be used to determine healthy, injured, and recovering gait.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierDamale_colostate_0053N_13325.pdf
dc.identifier.urihttp://hdl.handle.net/10217/170354
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectC-DIM 12
dc.subjectimage processing
dc.subjectmouse gait
dc.subjectMPTP
dc.subjectobject detection
dc.subject.lcshParkinson's disease
dc.titleDesign of a gait acquisition and analysis system for assessing the recovery in a classical murine model of Parkinson's disease
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineElectrical and Computer Engineering
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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