Mycobacterial arabinan biosynthesis : characterization of AftB and AftC arabinosyltransferase activity using synthetic substrates
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Tuberculosis (TB) is a chronic infectious disease caused by M. tuberculosis (Mtb). Treatment of TB is prolonged, and multidrug resistant (MDR-TB) and extensively drug resistant TB (XDR-TB) cases are ever increasing. Efforts to discover and develop new drugs have increased in recent years so improvement of the existing therapies is urgently needed. The cell wall of Mtb with its unique physiological properties has historically been an important and valid drug target. Mycobacterial arabinosyltransferases are membrane bound glycosyltransferases involved in the biosynthesis of the arabinan portion ...