The role of CACNβ4 in zebrafish development
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The calcium channel β4 subunit (CACNβ4) is an intracellular auxiliary protein of voltage-gated calcium channels. It is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Mutations in the CACNβ4 subunit are associated with ataxia and seizures in mice and with epilepsy in humans. Since known mutant alleles of CACNβ4 are not embryonic lethal in mammals, the developmental functions of the protein are unclear. The best characterized role for the β4 subunit is to facilitate the translocation of the calcium channel α subunit to the plasma membrane and the modulation of ...