Pathogenesis of experimental tuberculosis in guinea pigs
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Tuberculosis is an important infectious disease of humans that can be modeled in a number of small laboratory animal species. In humans and guinea pigs, infection with the causative agent Mycobacterium tuberculosis, incites a chronic inflammatory response in the lung (pulmonary) and other (extra-pulmonary) tissues and organs of the body. Granulomatous inflammation can become organized into a distinct inflammatory mass referred to as a granuloma. Granuloma formation is thought to represent a favorable host response that functions to contain the infection, thus preventing spread within or between ...