Initial development of a multistage cancer model based on Syrian hamster embryo (SHE) cell transformation studies
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To better incorporate biologic information into quantitative cancer modeling, the two-stage MVK (Moolgavkar-Venzon-Knudson) model has been modified for use with SHE cell neoplastic progression. Conceptually, five phenotypic stages are included in this model: normal cells can either become senescent or mutate into immortal cells followed by anchorage-independent growth and tumorigenic stages. Cells in each stage have distinct division, death and mutation rates, and mutation is assumed to occur during cell division. Model development and related experiments were focused on studying the abilities ...
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Criteria for evaluating model deficiency for groundwater models and the effects of eliminating deficient models on multi-model analysis using AICC, KIC, AIC, and BIC Contributor:Schenk, Judith A.;
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