Initial development of a multistage cancer model based on Syrian hamster embryo (SHE) cell transformation studies
MetadataShow full item record
To better incorporate biologic information into quantitative cancer modeling, the two-stage MVK (Moolgavkar-Venzon-Knudson) model has been modified for use with SHE cell neoplastic progression. Conceptually, five phenotypic stages are included in this model: normal cells can either become senescent or mutate into immortal cells followed by anchorage-independent growth and tumorigenic stages. Cells in each stage have distinct division, death and mutation rates, and mutation is assumed to occur during cell division. Model development and related experiments were focused on studying the abilities ...
Showing items related by title, author, creator and subject.
Criteria for evaluating model deficiency for groundwater models and the effects of eliminating deficient models on multi-model analysis using AICC, KIC, AIC, and BIC Contributor:Schenk, Judith A.;
Date Submitted:2017Multi-model analysis (MMA) considers multiple model interpretations of a system. MMA provides a more realistic assessment of uncertainty associated with model predictions because both uncertainty of individual models and ...
Multi-scale modeling and analysis via surrogate modeling techniques for in vivo knee loading predictions Contributor:Adams, Matthew J.;
Date Submitted:2014Total knee replacement is a viable treatment for end-stage knee arthritis. With a greater number of younger patients opting for total knee replacement surgery, their increasingly active lifestyles will result in higher ...
Date Submitted:2016As large magnitude wildfires persist across the western United States, understanding their impact on hydrologic behavior and predicting regional streamflow response is increasingly important. Peak flows, sediment flows, ...