Modeling human immunodeficiency virus-1 (HIV-1) infection in the male reproductive tract (MRT) using humanized mice
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Thirty-five million people are currently living with human immunodeficiency virus (HIV) globally. While 9.7 million infected people are receiving antiretroviral therapy, 2.3 million people are newly infected every year. Transmission via semen is one of the most prevalent methods of HIV-1 transmission, accounting for up to 80% of new infections every year. However, the source of infected leukocytes and the method of virus replication in semen and/or in the male reproductive tract (MRT) is not well described. It has been shown that infected germinal cells such as spermatogonia and spermatocytes ...