Tissue-specific seasonal changes in mitochondrial respiratory function and membrane composition in the golden-mantled ground squirrel
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Mammals that hibernate, such as the golden-mantled ground squirrel (Callospermophilus lateralis; GMGS), cease to feed, reduce metabolic rate, and lower body temperature (Tb) during the winter months, surviving almost exclusively on the oxidation of lipids from endogenous fat stores. Whether mitochondria, the cellular sites of oxidative metabolism, undergo changes in response to low Tb, hypometabolism, and decreasing ambient temperature (Ta) to facilitate this remarkable phenotype is unclear. It has been postulated that changes in mitochondrial membrane composition reported in response to cold ...