Flux balance analysis of metabolic models : a review of recent advances and applications
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Genome-level reconstructions of metabolic networks have provided new insight into the cellular functions of many organisms. These metabolic models are massive constructs, often including thousands of metabolic and transport reactions and metabolite species for even the most basic organisms. Construction of these models has typically involved an initial genomic analysis to identify known genes or genes with homologous structures for which the function may be inferred, followed by an intensive process of literature searching and experimental validation to refine the model. A number of automated ...