Membrane Adsorbers and Novel Affinity Peptides for Recombinant Protein Purification
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The purification of recombinant proteins for use as pharmaceutically active ingredients represents one of the largest costs of drug development and production. Of the different classes of recombinant protein therapeutics monoclonal antibodies represent the largest percentage of protein therapeutics currently on the market with even more in clinical development. The work presented in this thesis describes the evaluation of both commercial and newly designed anion exchange and hydrophobic interaction (HIC) membrane adsorbers as well as identification of novel affinity peptides for the purification ...