Mathematical modeling of hepatic and adipose insulin resistance in girls with polycystic ovarian syndrome
MetadataShow full item record
Polycystic Ovarian Syndrome (PCOS) affects 6-10% of women in the United States and is one of the leading causes of infertility. The metabolic phenotype for PCOS includes insulin resistance (IR), and IR may vary with tissue type. The goal of this project is to determine the contributions of hepatic (liver) tissue and adipose (fat) tissue to increased IR in a cohort of adolescent females. For hepatic IR, we use the Labeled Oral Minimal Model (OMM*), originally developed by Dalla Man and colleagues. This differential equations based mathematical model describes the dynamics of glucose and insulin ...