Biophysical mechanisms regulating Von Willebrand disease, arterial thrombosis, and deep vein thrombosis in microfluidic models of vascular injury
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Thrombus formation is regulated by biophysical mechanisms in ways that are not fully understood. Platelets are transported to injuries at rates that depend not only on the bulk flow, but also collisions with red blood cells (RBC). Their ability to tether to the subendothelium depends on shear stresses at the injury and can be impaired by deficiencies in Von Willebrand factor (VWF). The subsequent rate of fibrin formation is a function of the mass transfer of coagulation factors and of surface reaction rates. In this thesis, I detail studies of these biophysical mechanisms using microfluidic ...