The role of co-activating factors in the HIF-mediated hypoxia response
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In response to hypoxia, cells mediate expression of genetic programs through stabilization of HIF1α and HIF2α hypoxia inducible transcription factors. Activation of HIF target genes promotes cell proliferation, apoptotic resistance, metabolic adaptation, and tissue angiogenesis in normal physiologic as well as pathophysiologic processes including tumorigenesis. Data suggests that HIF1 and HIF2 play different roles in cancers derived from different types of tissues, sometimes even opposing each other's function. While reported differences in target gene specificity between HIF1 and HIF2 likely ...