Thyroid hormone responsive protein Spot14 modulates fatty acid synthase kinetics and fatty acid products
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The mammary gland synthesizes and secretes a complex fluid, milk, that is balanced in nutrient content and uniquely tailored to the growth and development of the neonate. Milk is comprised of three primary nutrients including carbohydrates, proteins, and fats. The fat component, triglycerides, is an amalgam of fatty acids either taken up by the mammary epithelial cell (MECs) from dietary and adipose sources, or synthesized by the MECs via the de novo fatty acid synthesis pathway. Fatty acids are synthesized in the cytosol using three enzymes, ATP citrate lyase (ACLY), Acetyl-CoA carboxylase ...