Investigation into the role of innate immunity in murine models of acetaminophen-induced liver injury and diet-induced obesity
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Drug-induced liver injury (DILI) represents a leading cause of adverse drug reactions, as well as the most frequent cause of safety-related drug market withdrawal and prescription restriction. At present, the murine model of acetaminophen (APAP)-induced liver injury (AILI) is the most widely used animal model to study the mechanism of DILI. The pathogenesis of APAP-induced hepatotoxicity consists of both direct cellular damage as well as involvement of the innate immune system. Herein we examine both molecular and cellular mechanisms involved in the progression of tissue injury in AILI. Here ...