A tale of two IRESes: translational regulation mediated by the eukaryotic FMR1 and Aurora A IRESes in disease
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Regulation of translation initiation of most eukaryotic mRNAs occurs in a cap-dependent manner. In this study I demonstrate how misregulated translation of two eukaryotic mRNAs via internal ribosomal entry sites (IRESes) contributes to two otherwise unrelated diseases. The 5'leader of the FMR1 gene contains high guanosine/cytosine nucleotide content, including the CGG trinucleotide repeats associated with Fragile X Syndrome. The focuses of my study were to confirm and extend a previous observation that the FMR1 5' leader contains an IRES. A combination of reporter assays did confirm the FMR1 ...