On the control and coordination of septin protofilament assembly
MetadataShow full item record
Septin filaments are long cytoskeletal polymers of oligomeric, rod-shaped protein complexes attached end-on-end. These complexes, called protofilaments, contain 3-4 different GTP-binding septin subunits assembled as hexamers or octamers. Septins have many different roles in human cellular physiology, made possible by the wide variety of septin subunits encoded in the human genome. All together, human septins are theoretically competent to assemble into 4992 different protofilament species, with the few that have been experimentally verified tending to exhibit distinct functional characteristics. ...