Tryptophan catabolism promotes triple-negative breast cancer metastasis
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The studies in this dissertation were designed to explore potential therapeutic targets in triple-negative breast cancer (TNBC) based on genes expressed under anchorage independent conditions since TNBC has the worse prognosis of the three main subtypes of breast cancer because it rapidly and frequently becomes metastatic . TNBC, characterized by lacking expression of estrogen receptor alpha (ER), progesterone receptor (PR), and HER2 amplification, represents the most aggressive subtype of breast cancer that currently has no effective targeted therapies. Compared to other breast cancer subtypes, ...