The regulation of myeloid cell IFNGR1 expression during infection and inflammatory disease
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IFNs target macrophages to regulate inflammation and resistance to microbial infections. The type II IFN (IFNγ) acts on a cell surface receptor (IFNGR) to promote gene expression that enhances macrophage pro-inflammatory and antimicrobial activity. In contrast, type I IFNs contribute to host susceptibility to several intracellular bacterial pathogens including Listeria monocytogenes. While the precise mechanisms responsible for these effects remain unclear, type I IFNs can dampen macrophage responsiveness to IFNγ through the silencing of macrophage ifngr1 transcription and thus reduce cell surface ...