Fine mapping of Serpine1 and Serpine2 gene regions association with coronary artery disease in a chronic obstructive pulmonary disease cohort
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Coronary artery disease is a costly public health burden and understanding the genetic architecture of this disease would allow better risk stratification and targeted therapies for both primary and secondary prevention. The COPDGene Study provided an opportunity to investigate the genetic variants in both plasminogen activator inhibitor-1 (SERPINE1) and protease nexin-1 (SERPINE2) genes and their associations with coronary artery disease in African American and non-Hispanic European ancestry cohorts. The study evaluated both single variants and a gene-based approach in assessing these genes’ ...