Targeting the DNA-binding domain of signal transducer and activator of transcription-3 (STAT3) with small molecule therapeutics
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The signal transducer and activator of transcription (STAT) family of proteins is a group of transcription factors that regulate gene expression related to cell cycle, cell survival, and immune response. Constitutively active STAT3 has been shown to promote the induction and survival of cancer. Given its critical role in both tumor onset and progression, STAT3 has emerged as an attractive target for small molecule therapeutics. The disparity between assays and assay conditions reported in publications for assessing STAT3 inhibitors makes it difficult to compare the potency of one compound to ...