Studies on cardiac pacemaking: restoring the effects of aging and characterization of the funny current
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Cardiac pacemaking is initiated in the sinoatrial node by spontaneous action potentials (APs) in specialized cells, called sinoatrial node myocytes (SAMs). APs in SAMs are triggered by the spontaneous depolarization of membrane potential during diastole, called the diastolic depolarization. The diastolic depolarization and APs are produced by the coordinated activity of ion channels and calcium signaling in SAMs. One of the currents thought to underlie this spontaneous activity, and a distinguishing feature of SAMs, is the funny current (If). Despite evidence to support a role for If in pacemaking, ...