Loss of EBF family transcription factor function drives leukemogenesis and impairs neuronal development
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Early B cell factor (EBF) genes 1-4 encode a family of highly conserved transcriptional regulators that are differentially expressed across select tissues in both mammals and insects. Two of these proteins, EBF1 and EBF3, activate lineage specific gene programs in developing B lymphocytes and Cajal-Retzius neurons, respectively. Despite 25 years of study, a complete mechanistic understanding of how these “master regulators” drive normal development and prevent disease has yet to be achieved. This dissertation combines data generated from two separate projects related to EBF family proteins. ...