Exploring the landscape of allele-specific expression in nasal epithelium of asthmatic patients and simulating allele-specific read counts accounting for correlation
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Allele-specific expression (ASE) describes differential mRNA expression between pairs of chromosomes within an individual, also referred to as allelic imbalance. Current methods for detection of ASE do not combine information across heterozygous single nucleotide variants (SNV’s) within a gene using methods grounded in statistical theory. Gaining an understanding of the degree of correlation between variants within a gene will better inform the most appropriate statistical approach for combining tests of ASE at the gene level. Therefore, we aimed to determine whether correlation exists in ...