The role of brain acetaldehyde in drinking preference: genetic modification of alcohol oxidizing enzymes catalase and CYP2E1 in C57BL/6 mice and their characterization
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EtOH-derived acetaldehyde is believed to influence alcohol drinking preference behavior as evidence in literature shows acetaldehyde in the central nervous system can increase alcohol consumption as measured by conditional place preference and increases dopamine release. The work presented in this dissertation evaluates the behavioral effects of acetaldehyde through the use of genetically modified mouse models lacking the enzymes (catalase and Cyp2e1) that are primarily responsible for acetaldehyde formation in the brain. Through animal husbandry, double knockout mice deficient in both catalase ...