Regulation of histone reader binding by histone post-translational modifications and multi-domain crosstalk
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The accessibility of eukaryotic DNA depends on the compaction of chromatin, and ultimately on the position and dynamics of nucleosomes. The nucleosome undergoes a wide array of epigenetic modifications on DNA and histones that regulate its structure and function. A network of effector proteins interprets these modifications and modifies the genomic landscape by recruiting chromatin-modifying enzymes. In this Thesis, I define the molecular basis of histone recognition by two key classes of epigenetic modules, the Tudor domain and the PHD finger, and investigate the mechanisms that regulate their ...