The role of PIK3CA in head and neck cancer progression
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Head and neck squamous cell carcinoma (HNSCC) patients have a poor prognosis, with invasion, recurrence and metastasis as major causes of mortality. Currently, effective therapeutic options for advanced HNSCCs are still limited. The phosphatidylinositol 3-kinase (PI3K) pathway regulates a wide range of cellular processes crucial for tumorigenesis, and PIK3CA amplification and mutation are among the most common genetic alterations in HNSCC. Compared to the well-documented roles of the PI3K pathway in cell growth and survival, its roles in tumor invasion, recurrence and metastasis have not been ...