Differential correlation in high-throughput data
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Differential correlation or coexpression occurs when feature pairs (e.g. transcripts, proteins, or metabolites) have different types of associations between biological groups. Differentially correlated feature pairs may indicate processes or interactions that are unique to disease. Differential correlation can be categorized into different types. Disrupted differential correlation is when there is no association in one group, but an association in the other group. Cross differential correlation is when there is a positive association in one group, but a negative association in the other group. ...