Innate immune activity of xylitol-headgroup lipid analogs of the anionic pulmonary surfactant phospholipids
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Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in newborns, the elderly, and those with chronic respiratory disease. There is no vaccine for RSV, no natural development of enduring immunity, and reinfection occurs throughout life. Currently, there is an urgent need for new approaches to prevent and treat RSV infection. Phospholipids are the major constituents of pulmonary surfactant and play critical roles in regulating immune functions of the lung. Previous studies reported that the minor pulmonary surfactant lipid, palmitoyl-oleoyl-phosphatidylglycerol ...