Transcriptional regulation of hypofunction in tumor-specific CD8+ T cells
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Functional CD8+ tumor-infiltrating lymphocytes (TIL) positively correlate with improved cancer patient survival. However, mechanisms of self-tolerance often result in TIL with a hypofunctional phenotype incapable of tumor clearance. Using a solid tumor model in mice, we found that CD8+ T cells became tolerized in less than 24 hours in an established tumor environment. To define the collective impact of pathways suppressing TIL function, we compared genome-wide mRNA expression of tumor-specific CD8+ T cells from the tumor (hypofunctional T cells) and periphery (functional T cells). Notably, gene ...