mTOR complex 1 regulates translation initiation events of (+)-sense RNA viruses
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Since the introduction of West Nile virus in New York City in 1999, West Nile virus (WNV) has spread to all 48 contiguous United States and is now the leading cause of epidemic encephalitis in North America. As member of the family Flaviviridae, WNV is part of a group of clinically-important human pathogens including Dengue virus, Zika virus, and Japanese encephalitis virus. This family of (+)-sense, single stranded RNA viruses have limited coding capacity and are therefore obligated to co-opt cellular factors in order to translate their RNA genomes. Our previous work has shown that WNV growth ...