Role of oxidative stress on the temporal development of morbidity and mortality following sulfur mustard inhalation
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Sulfur mustard (bis 2-chloroethyl ethyl sulfide, SM) is a powerful bi-functional vesicating chemical warfare agent. SM tissue injury is partially mediated by the overproduction of reactive oxygen species resulting in oxidative stress. It was hypothesized that mitigating the oxidative stress component of SM induced injury would alleviate the toxic effects of SM inhalation. To test this hypothesis, adult Sprague-Dawley rats were intubated and exposed to a lethal dose of SM (1.4mg/kg). Suppression of oxidative stress was achieved through repeated dosing of the catalytic antioxidant AEOL 10150. Rats ...