Cholesterol synthesis requirements in oligodendrocyte development and myelination
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Sensation, movement, and cognition require the rapid and highly coordinated conduction of nerve impulses over long distances. Rapid impulse conduction is facilitated by myelin, a highly specialized proteolipid and cholesterol rich membrane that ensheathes axons. Myelin also is required for the long-term health of axons. Accordingly, myelin deficiencies are implicated in a wide range of neurodevelopmental, neuropsychiatric, and neurodegenerative conditions. Central nervous system (CNS) myelin is formed by glial cells called oligodendrocytes. During development, oligodendrocyte precursor cells ...