Roles of interferon stimulated genes in Human papillomavirus infection and cancer progression
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HPVs are potent human pathogens causally associated with multiple malignancies, including cervical, head and neck and anogenital cancers. While it is well known that HPV persistence is a necessary event in cancer development, it is unclear how host cells efficiently clear most infections. Initial detection and response to viral infections is mediated by the innate immune system. This thesis focuses on furthering our understanding of the roles of innate immune system in modulating HPV infections by exploring the roles of interferon (IFN) and IFN stimulated genes (ISGs) during HPV infection and ...