Cellular and molecular investigations of non-neural ectoderm during murine neural tube closure
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Neural tube closure is a highly complex morphogenetic process whereby three adjoining tissues work in concert, bringing opposing neural folds together to seal at the midline and form the primordial central nervous system. The non-neural ectoderm (NNE) lies first adjacent to, and then overlies, the neural tube, which is composed of neural ectoderm (NE). The neural crest cells (NCC) arise from the epithelial layer at the border of the NE and NNE, undergo an epithelial-to-mesenchymal transition (EMT), and migrate to distal sites to form various structures. It has been shown previously that the NNE ...