Role of domain unfolding and silicone oil-water interface in aggregation of a monoclonal antibody
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Monoclonal antibodies (mAbs) are an important class of therapeutic protein drugs that have been developed by pharmaceutical companies to treat major diseases. However, aggregation of mAbs is of major concern for pharmaceutical industry because it can affect product efficacy and can lead to immune response in patients. Reported incidences of immune response in patients range from 3-100%. Monoclonal antibodies fall under the category of multi-domain proteins where each domain contributes to the overall stability of the protein. In this work we found that partial unfolding of a monoclonal antibody ...