The actively myelinating oligodendrocytes: signaling mechanisms and response to injury
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The actively myelinating oligodendrocyte is vital for the normal development and proper function of the central nervous system (CNS). Despite significant progress in recent years, many fundamental questions remain regarding the cellular and molecular properties of oligodendrocytes. In this dissertation, we first sought to identify and characterize putative negative regulators of CNS myelination. We identified Shp2, a protein tyrosine phosphatase, as a potential negative regulator of CNS myelination using a candidate based approach and expression profiling of mRNA and protein during development ...