The anti-insulin B cell receptor in autoimmune diabetes
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B cells are required during the pathogenesis of autoimmune diabetes and this functionality is independent of antibody secretion, but dependent on MHC expression and B cell receptor (BCR) specificity. Together, this suggests that autoreactive B cells drive diabetes by presenting antigen to effector T cells. An insulin-binding BCR is sufficient for diabetes development in NOD, but monoclonal transgenic (125Tg) have reduced disease compared to polyclonal transgenic (VH125) animals. This prompted us to investigate the insulin-binding affinities of BCRs derived from the VH125 animal, and consequential ...