The role of APOBEC3 in the neutralizing antibody response to Friend retrovirus
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A vaccine that elicits HIV-1 broadly neutralizing antibodies (bNAbs) could significantly lower the risk of infection. However, HIV-1 bNAbs exhibit unprecedented levels of somatic hypermutation (SHM) and often have essential framework region mutations. These properties are not typically induced by current vaccination methods. Activation induced deaminase (AID) is thought to be the only initiator of SHM. However, in the Friend retrovirus (FV) model, an evolutionary descendent of AID, APOBEC3 (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3), has been shown to modulate the ...