Interactions between therapeutic protein formulations and surfaces
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Therapeutic protein formulations encounter a multitude of different surfaces in every part of their production, packaging, storage and administration to patients. These interfaces can be very different---chemically---from the formulation's solution chemistry and can have unintended, negative effects on the formulation. Protein molecules can adsorb to these surfaces, which can induce structural perturbations in the therapeutic and promote aggregation. Components from the formulation can be absorbed into the surfaces, altering the formulation solution conditions, which can bring about additional ...