Rapid increases in ProBDNF after pilocarpine-induced status epilepticus in mice are associated with reduced ProBDNF cleavage machinery
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Brain-Derived Neurotrophic Factor (BDNF) expression is elevated after status epilepticus (SE), leading to rapid activation of multiple signaling pathways, including the Signal Transducer and Activator of Transcription 3 (STAT3) pathway that mediates a decrease in GABAᴀ receptor α1 subunit expression in hippocampus (Lund et al., 2008). While BDNF can signal via its pro- or mature form, the relative contribution of these forms to signaling after SE is not fully known. In the current study, induce SE in C57BL/6J mice. A thorough review of temporal lobe epilepsy models is reported with special ...