A simulation modeling framework to study transcriptional regulation through the dynamic changes in the configuration of DNA binding factors
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Transcriptional regulation is the complex system behavior arising from the interaction of numerous regulators with the DNA. The DNA sequence contains the information for this complex system to produce precise gene expression at specific times and cellular locations. Despite the tremendous progress in understanding the behaviors of individual components, we are unable to predict transcriptional behavior from the signal encoded in a DNA sequence. To better understand transcriptional regulation, we need to construct interpretable, quantitative models of the regulation processes derived from ...