Expression, potency, and antiviral mechanisms of the interferon-alpha subtypes in retroviral infection
MetadataShow full item record
More than 30 years after the first recognition of AIDS, HIV-1 infection remains an enormous public health burden globally. Understanding mechanisms of innate immunity to HIV-1 could fulfill the critical needs of novel antivirals, vaccines, or curative therapies. The Type I Interferons (IFN-I), in particular the IFN-alphas (IFN-α), are the first line of defense against HIV-1. The IFNA family in humans consists of 13 genes that all have a common receptor. The expansion of the IFNA family raises important evolutionary questions regarding their expression and potency against specific pathogens. While ...