Update on the distribution and evolution of the aldehyde dehydrogenase superfamily in vertebrates and biochemical and polymorphic characterization of human ALDH1B1
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The aldehyde dehydrogenase (ALDH) superfamily is a group of enzymes that catalyze the NAD(P)⁺-dependent oxidation of a wide variety of endogenous and exogenous aldehydes to their corresponding carboxylic acids. This family is present in all taxonomic lineages studied, including archaea, bacteria, and eukaryotes. As a torrent of new genomic data has become available over the past decade, there is now a need to organize and examine the evolution of this critical superfamily. To create a reference of the distribution and number of ALDHs in vertebrates, 11 representative species with completed genomes ...