Amino terminal cleavage and multisite phosphorylation regulate the function of the cohesin deposition factor, Scc2
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Sister chromatid cohesion plays vital roles in chromosome biology, including the regulation of gene expression, the facilitation of DNA repair, the mediation of chromosome condensation, and the tethering, or cohesion, of replicated sister chromatids to promote chromosome biorientation and proper segregation. The four-subunit cohesin complex mediates cohesion and its deposition onto chromosomes requires a separate conserved loading complex, composed of Scc2 and Scc4 (Scc2/Scc4) in budding yeast. How the Scc2/Scc4 deposition complex regulates the spatiotemporal association of cohesin with chromosomes ...