Contrasting roles of C/EBPα and notch in ionizing radiation-induced multipotent hematopoietic progenitor cell self-renewal defects
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Ionizing radiation (IR) is associated with persistent panhematopoietic defects and increased risk of carcinogenesis, although the mechanism underlying these relationship remains largely unknown. The increasing exposure of humans to man-made sources of IR, primarily through medical procedures, exemplifies a critical need to understand how IR elicits adverse health affects. Mice exposed to IR develop a disease similar to human T-cell acute lymphoblastic lymphoma, of which over 50% are associated with activating Notch mutations. Furthermore, our lab has previously shown that the activated ...